12th Annual NSRA Northeast Street Rod Nationals, Sept. 23-25, Champlain Valley Exposition, Route 15, Essex Junction, Vt. More than 1,500 colorful pre-1949 street rods, trade show, vintage auto parts swap meet, arts and crafts show. Show hours Sept. 23, 9 a.m. – 5 p.m.; Sept. 24, 8:30 a.m. – 5 p.m.; Sept. 25, 8:30 a.m.-2 p.m. Admission $12 for adults, $3 for children 6-12, under 5 is free when accompanied by an adult. For more information, 878-5545 or the Northeast Street Rod Nationals at (724) 932-3747 or visit www.nsra-usa.com(link is external).17TH ANNUAL VERMONT SHEEP AND WOOL FESTIVAL, Oct. 1-2, Champlain Valley Exposition, Route 15, Essex Junction, Vt. Saturday, 10 a.m. to 5 p.m., Sunday, 10 a.m. to 4 p.m. Vermont’s premier fiber event, with fleece, roving, and wool yarns from area producers. Visually stunning hand dyed wools, fine fibers and specialty foods. Eighty-plus vendors including farms with livestock for sale. Demonstrations and workshops offered. Admission is$5. Call (802) 446-3325 or visit www.vermontsheep.org(link is external)CHAMPLAIN VALLEY ANTIQUES FESTIVAL, Oct. 8-9, Champlain Valley Exposition, Route 15, Essex Junction, Vt. More than 200 dealers from the Northeast will display a full range of antiques, with 40 room settings. Named a 2005 “Top 10 Vermont Fall Event” by the Vermont Chamber of Commerce. Saturday, Oct. 8, 10 a.m. to 5 p.m. and Sunday, Oct 9, 10 a.m. to 4 p.m. Admission is $7 for adults and children 12 and under free. Special preview admission beginning at 9 a.m. on Saturday is $15. All exhibitors are indoors. Sponsored by the Lake Champlain Regional Chamber of Commerce and produced by New England Antique Shows of Lexington, Mass. For more information, www.antiquingvermont.com(link is external) or (781) 862-4039.SHRINERS BINGO, Oct. 9. Miller Expo Centre, Champlain Valley Exposition, Essex Junction, Vt. Variety of games, half-and-half, money machine. Open seating, concessions. No children under 12. All proceeds benefit Mount Sinai #3 Shrine Activities. For information, call (802) 434-2055 or (802) 878-1714.NINTH ANNUAL Blue’s MODEL HORSE SHOW, Oct. 15, 9 a.m. to 4 p.m., Champlain Valley Exposition, Route 15, Essex Junction, Vt. Admission is free. Presented by Guy’s Farm and Yard of Williston. Scale models of horses on display, competitions and hobbyist demonstrations. Information, 878-5112 or write [email protected](link sends e-mail).EVERYTHING FIT AND HEALTHY EXPO, Oct. 22, Champlain Valley Exposition, Essex Junction, Vt. A daylong event for children, adults, families and senior to learn more about healthy lifestyles, nutrition, exercise and lifestyle choices. Sponsored by the Champlain Initiative, United Way of Chittenden County, Vt. Dept. of Health and UVM Extension. Seminars, demonstrations and trade show. For more information, Suzie Petrie, (802) 878-5545 or Kimberley Legg at (802) 864-7541.WOKO GIANT FLEA MARKET, Oct. 23, 8:30 a.m. to 3 p.m., Champlain Valley Exposition, Essex Junction, Vt. Hundreds of tables and booths will be set up to sell collectibles, flea market and garage sale items, antiques and close-out items. Outdoor space available for motor vehicles, boats, RV’s, snowmobiles and other large items. Food concessions will be available. Tables and booths are still available for exhibitors and commercial vendors. Call Susan Petrie at (802) 878-5545 or email [email protected](link sends e-mail) to register in advance.
Small business lenders now have access to more in-depth information and resources on U.S. Small Business Administration loan programs through the new Lender Toolkit on the agency’s recently redesigned website.The new site strengthens SBA collaboration with its lending partners, making it easier for them to identify the points of contact, loan programs and financing options that will best expand access to capital for local small businesses to help them grow and create jobs.Elements of the streamlined Lender Toolkit include useful tools like the ability to download and submit loan packages, updates on interest rates and important lending news, all at www.sba.gov/for-lenders(link is external).‘Lenders are vital partners in our efforts to help entrepreneurs and small business owners grow successful companies and create good paying jobs in their communities,’ said SBA Administrator Karen G. Mills. ‘Over the last two years, we’ve worked hard to strengthen these partnerships. This new online toolkit puts more information on SBA loan programs at lenders’ fingertips and makes it easier for them to use these programs to meet the capital needs of their small business customers.’The online Lender Toolkit features:· Find a Loan Package, which allows users to select a loan type and download all the associated forms. Instruction on how to complete the loan package and standard boilerplates will help lenders prepare more accurate loan applications, increasing the probability of guarantees to worthy small businesses.· Find a Service Center enables the lender to search for servicing center contact information based on the loan processing parameters of loan type and stage. Lenders can also Find a Lender Relationship Specialist by selecting a local district office from a pull-down list.· Lender FAQs provide answers to questions about the SBA’s approach on the financing and underwriting of loans to small business owners.· Recent Standard Operating Procedure (SOP) notices, which display current versions of loan processing, servicing and liquidation documents along with a copy highlighting any updates.· Weekly Lending Report, which provides details on lending activity for SBA loan programs, along with comparisons for FY 2009, 2010 and 2011 for the period ending that week.The SBA’s commitment to transformation is reflected in the new Lender Toolkit, which is part of the redesigned SBA.gov website, which went live in December 2010. Designed to better meet the needs of small business owners and entrepreneurs, the enhanced website features SBA Direct, which allows visitors to seek information on starting or growing a business, financial assistance, and regulatory compliance based on their location, type of business, and specific needs. The project is also a flagship for the agency’s Open Government Plan, with the goal of building an online presence for SBA that is transparent, participatory and collaborative.
Aug 18, 2009 (CIDRAP News) – Half a century ago, scientists reported evidence of some curious behavior by the immune system in humans and animals: If a host was exposed to an influenza virus and later encountered a variant strain of the same virus, the immune system responded to the second attack largely with the same weapons it used against the first one.Like an army still fighting by the tactics of the last war, the host immune system mostly produced antibodies matched to the first virus instead of the second, resulting in a less effective defense. With a nod to theology, this phenomenon was labeled “original antigenic sin.”Today, in the face of the pandemic H1N1 flu virus, many countries are preparing to launch H1N1 vaccination campaigns this fall. Millions of people are in groups recommended to receive both seasonal flu immunizations and H1N1 vaccinations. Seasonal flu vaccine—which contains an H1N1 component, distantly related to the novel H1N1 virus—will be available sooner in most places.This timing has caused some observers to wonder: If a person gets a seasonal flu shot and then an H1N1 dose a few weeks later, will original antigenic sin come into play and cause a poor response to the H1N1 vaccine?Nobody knows the answer for sure, but leading flu and immunization experts say they aren’t especially worried at this point. At the same time, they suggest the possibility bears watching.”For the time being there is no cause for worry especially for vaccines because the influenza vaccines are really . . . very well known in terms of the seasonal use of these,” said Dr. Marie-Paule Kieny, director of the World Health Organization’s Initiative for Vaccine Research, in a recent news briefing.But there is enough concern so that the H1N1 vaccine clinical trials recently announced by the National Institute of Allergy and Infectious Diseases (NIAID) will look into the question. Two of the trials will examine whether giving an H1N1 vaccine and seasonal flu vaccine sequentially or simultaneously affects the immune response to either vaccine, according to the NIAID’s descriptions of the trials.Study raises issue anewA study published recently by the Journal of Immunology raised anew the question of original antigenic sin. Saying that some recent studies have raised doubts about the existence of the phenomenon, scientists at the Emory University Vaccine Center in Atlanta used three different approaches to look for evidence of original antigenic sin in mice. They found evidence of it under certain conditions.The scientists used two human H1N1 viruses, labeled PR8 and FM1, that emerged in the 1930s and 1940s. They sequentially immunized mice with conventional vaccines using inactivated viruses, and they immunized other mice with DNA vaccines that encoded the hemagglutinin proteins from the two strains. In a third experiment, they sequentially exposed mice to the live viruses. The interval between the two inoculations in most cases was 1 month.In the mice sequentially immunized with conventional vaccines, the team found minimal differences in antibody responses to the two strains. However, when the mice were then challenged with a high dose of the FM1 virus, the virus multiplied in their lungs far more than it did in the lungs of control mice that had received only the FM1 vaccine.When mice were sequentially immunized with the DNA vaccines, the team found that the antibody response to the FM1 vaccine was oriented to the PR8 (original) vaccine, and antibodies to the FM1 strain were reduced, according to the report.However, the original antigenic sin effect was much stronger in the mice that were infected with the two live viruses. “Sequential infection with live viruses generated severely reduced neutralization Ab [antibody] responses and compromised memory responses to the second virus,” the report states. The authors suggest that this phenomenon helps explain the success and prevalence of flu viruses: when they mutate, the host immune system is fooled into responding to the predecessor strain instead of the mutated one.Antigenic distance is keyOn the other hand, original antigenic sin occurs only when the new strain is closely related to one the host has seen before, the scientists write. It is not known exactly how much antigenic similarity (likeness in the amino acid sequences of the hemagglutinin protein of the two strains) between the two strains is necessary to fool the immune system, but past studies have shown that antigenically distant or dissimilar strains fail to trigger original antigenic sin.That finding seems to suggest that original antigenic sin would not be induced by a novel H1N1 immunization soon after getting a seasonal flu vaccine, as the new virus is not considered a close relative of the H1N1 strain in the seasonal vaccine.In fact, that’s the view of Robert G. Webster, PhD, a highly respected virologist and flu expert who did some of the original research on original antigenic sin decades ago. He is based at St. Jude Children’s Research Hospital in Memphis.”The antigenic distance between the seasonal H1N1 and swine flu is very large, so I don’t think original antigenic sin is going to be a problem,” Webster said in a recent interview.He said that even if the phenomenon did arise, it might be possible to overcome it by using one of the newer vaccine adjuvants or by increasing the dose of vaccine. “With a larger dose, you can negate the original sin by sort of flooding the receptors with sufficient antigen to negate it,” he said.Jin H. Kim, PhD, a postdoctoral research associate at Emory and the lead author of the recent study, said the type of vaccine is important. He noted his finding that original antigenic sin was minimal when inactivated virus vaccines were used. Similarly, he said by e-mail, two recent studies found little evidence of original antigenic sin when humans received an inactivated vaccine against one seasonal flu strain and later were vaccinated against a drifted variant of that strain.What about live-virus vaccines?However, the finding that sequential exposure to live viruses invoked a greatly reduced response to the second virus raises the question whether the use of live attenuated vaccines for seasonal flu and the novel virus could lead to a similar response, Kim noted by e-mail. MedImmune, maker of the live attenuated seasonal vaccine FluMist, is also making a live version of novel H1N1 vaccine.”It is [an] intriguing question whether the live attenuated vaccines would induce original antigenic sin,” Kim said. “Our data show that sequential infection with related H1N1 viruses causes significant original antigenic sin and dampens the development of protective immunity. Therefore, it is possible that live attenuated swine origin H1N1 virus vaccine may behave similarly. However, it is important to note that we have not tested this in humans, thus this would be an immature conclusion at this point.” What if seasonal flu and novel H1N1 immunizations are given at the same time? John Treanor, MD, a vaccine researcher at the University of Rochester, said interference between the two vaccines is not likely to be a problem.He noted that the seasonal vaccine itself normally contains three different strains of flu virus, and interference isn’t a big concern. “In the absence of data, it’s hard to be completely confident about the potential for interference when the seasonal vaccine is given at the same time as the H1N1 vaccine, but I think the hypothesis is that there will not be interference between components,” he said.Treanor commented that when two vaccines must be given in sequence rather than simultaneously, his view is that they should be separated by at least 2 weeks, mainly to prevent any confusion about attributing side effects. Cautioning that he is not an expert on original antigenic sin, he added, “I do not know if there is really any data that would suggest that such a schedule would or would not result in a decrease in the response to the novel H1N1 (or who knows, maybe an increase),” he said.For Webster, original antigenic sin is only a minor concern in the current situation with regard to H1N1 vaccination.”At the moment it’s not a big issue, in my opinion,” he said. “It’s something we have at the back of our minds that we’ll watch for. The new H1N1 is antigenically stable, vastly different from the seasonal H1N1, and we need to have vaccine for it wiki-wiki [very fast].”See also: Kim JH, Skountzou I, Compans R, et al. Original antigenic sin responses to influenza viruses. J Immunol 2009 (early online publication Jul 31) [Abstract]Transcript of Aug 6 WHO news briefinghttp://www.who.int/mediacentre/pandemic_h1n1_presstranscript_2009_08_06.pdfDescription of NIAID-sponsored trial examining sequential and simultaneous immunization of adults with seasonal and H1N1 vaccines from Sanofi Pasteurhttp://clinicaltrials.gov/show/NCT00943878Description of NIAID-sponsored trial examining sequential and simultaneous immunization of children with seasonal and H1N1 vaccines from Sanofi Pasteurhttp://clinicaltrials.gov/show/NCT00943202
With just two outs to go before finishing the no-hitter, Lipka decided to bunt on the first pitch he saw. It went down the first base line and he was safe at first.MORE: Watch ‘ChangeUp,’ a new MLB live whiparound show on DAZNHere is the bunt that broke up the @GoYardGoats no-hit bid in the 9th. What does Hartford starter Rico Garcia think of it? 👉 https://t.co/JKJTmZDBEb pic.twitter.com/24r6ZHwEj4— Minor League Baseball (@MiLB) June 5, 2019Bunting to break up a no-hitter is an unwritten rule in baseball (even though some agree it’s a stupid rule).So when it happens, feelings get hurt. And that was the case Tuesday night as the benches cleared after the single.Aftermath of a near fight at the end of the @GoYardGoats and @TrentonThunder game at Dunkin’ Donuts Park. 3-0 win for the Goats allowing only one hit as a team. #NoGoatsNoGlory #Pride #NBCCT @NBCConnecticut @GLucivero pic.twitter.com/N1QL5XUWFo— Paul Ross (@RealPaulRoss) June 5, 2019While there was clearly overall frustration by the team, Garcia wasn’t too upset by the act itself. But he certainly wanted to see his team finish the no-hitter.”It is what it is,” Garcia said, via MILB.com. “[Lipka] was doing what he had to do. And we were really passionate about getting the no-hitter. It is what it is. I can’t really speak for what he was trying to do or what he was trying to accomplish. It’s unfortunate we couldn’t get the no-hitter. Emotions were high after.”The Thunder finished with the lone hit and lost the game 3-0 as Bowden safely recorded the next two outs. The Hartford Yard Goats were carrying a no-hitter heading into the ninth inning Tuesday night against the Trenton Thunder, but then things got a little out of hand.Starting pitcher Rico Garcia did most of the damage, pitching six innings and recording 11 strikeouts. Then relievers Jordan Foley and Logan Cozart each pitched one inning without allowing a hit. Ben Bowden came in for the save, and recorded one out before facing Trenton’s Matt Lipka. UPDATE: According to NJ.com’s Mike Rosenstein, Lipka was the victim of online harassment following his decision to bunt.Via NJ.com:According to a source not authorized to speak on behalf of the Thunder organization, the 27-year-old Lipka received death threats on social media following Tuesday’s game. The Thunder are the Double-A affiliate of the New York Yankees. The source says the Yankees have been alerted to the threats and are investigating.It’s worth noting Lipka got on base while the game was still close. If just one other batter had gotten on base after him, then the tying run would have been at the plate.
COMMUNITY SERVICE AWARD—Jeff Marion holds his Pa. Proclamation he received from State Rep. Ed Gainey for “Excellence in Service Rendered to the Community.”Jeff Marion recently received a proclamation from State Rep. Ed Gainey for “Excellence in Service Rendered to the Community. ”The proclamation stated that coach Marion far exceeded the communities’ expectation as a coach of youth football, basketball and baseball.Marion stated that it all is his way of giving youth something positive to do all year long and keeping them off the streets. Marion coaches in several youth leagues in an attempt to help youth gear their energy in a positive direction through sports.Marion is also the circulation manager for the New Pittsburgh Courier.