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New Gene Responsible for Male-Pattern Baldness Identified

first_imgBy Dialogo April 16, 2010 What we want to know is what kind of substances and drugs can stimulate the WNT pathway to promote the growth of follicles and solve the baldness problem. There are no known substances or drugs that can block the gene that causes baldness or silence it through epigenetic substances. The WNT pathway is one that may be linked to prostate cancer. Researchers have identified a new gene involved in hair growth, a discovery that may open the way to future treatments for male-pattern baldness and other forms of hair loss, according to a study published in the journal Nature. The team, led by Angela Christiano (Columbia University, United States), identified a gene called APCDD1 that causes a rare form of hair loss, hereditary hypotrichosis simplex. This disease is the result of hair-follicle miniaturization, a process also observed in male-pattern baldness: individual hairs are increasingly thinner. “The identification of this gene underlying hereditary hypotrichosis simplex has afforded us an opportunity to gain insight into the process of hair-follicle miniaturization, which is most commonly observed in male-pattern hair loss,” Angela Christiano indicated. Nevertheless, “it is important to note that while these two conditions share the same physiologic process, the gene we discovered for hereditary hypotrichosis does not explain the complex process of male-pattern baldness,” she added. The identification of the APCDD1 gene was possible thanks to the analysis of the genetic data of a number of Pakistani and Italian families who carry the gene that causes hereditary hypotrichosis simplex. The researchers discovered a mutation in the APCDD1 gene, located in a region of chromosome 18, which has been suggested by previous studies to be involved in other forms of hair loss. The researchers showed that the APCDD1 gene inhibits a cellular signaling pathway known as Wnt, the role of which in the control of hair growth has been demonstrated in mice. “These findings suggest that manipulating the Wnt pathway may have an effect on hair-follicle growth – for the first time, in humans,” Angela Christiano declared.last_img read more

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Bruins rally back to edge Leafs 4-3 in Boundary City

first_imgHowever, Dylan Haney scored late in the second frame to cut the advantage to 3-2.Rylan Smaha-Muir tied the game on the power play midway through the third period before Hascarl completed the rally.Chad Grambo scored the other goal for Grand Forks, winners of two straight games.Grand Forks out shot the Leafs 26-20 in the contest.Bruins’ netminder Anthony Galliart won for the third straight time against the Leafs while Zakery Babin, making his second start for Nelson, took the loss in goal.Babin was acquired earlier this month in a deal with the Princeton Posse.Nelson travels to the Hawks Nest to meet Murdoch leading Beaver Valley Friday in Fruitvale before returning home to host former Leaf netminder Brett Soles and the Osoyoos Coyotes Saturday at 7 p.m. in the NDCC Arena.The Hawks routed Spokane 8-2 Tuesday in Fruitvale to move into a first-place tie with Castlegar in Murdoch Division standings.Beaver Valley has two games in hand on the Rebels. The Grand Forks Border Bruins rallied from a two-goal deficit to edge the Nelson Leafs 4-3 in Kootenay International Junior Hockey League play Tuesday night in the  Boundary City.The loss continues the recent slide of the Heritage City franchise, losers of five consecutive games and 12 of 14 games dating back to October 31.Logan Hascarl scored with five minutes remaining in the third period to complete the comeback and give the Bruins its third consecutive win over the Leafs in the battle of the two Murdoch Division rivals.Grand Forks also builds a three-point lead over the Leafs for third spot in Murdoch standings.Goals by Sam Weber, Austin Anselmo and Aigne McGeady-Bruce built a 3-1 lead for the Leafs less than a minute into the second period.last_img read more

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first_imgARCADIA, Calif. (AP) _ Shaman Ghost beat Midnight Storm by three-quarters of a length to win the $750,000 Santa Anita Handicap on Saturday.Ridden by Javier Castellano, Shaman Ghost ran 1 1/4 miles in 2:01.57 and paid $4.60, $2.60 and $2.40 as the 6-5 favorite.Owner-breeder Frank Stronach was on hand to see his 5-year-old horse win a big race at Santa Anita, which Stronach also owns. Last November, Shaman Ghost was scratched from the Breeders’ Cup Classic on race day at the track after falling ill.Stronach won his third Big `Cap; Milwaukee Brew won in 2002 and ’03.“I was kind of sitting there quiet (watching the race),” he said. “He’s had a lot of bad racing luck and he’s better than what he has shown. Today it all worked out.”In January, Shaman Ghost finished second to Eclipse Award winner Arrogate in the $12 million Pegasus World Cup at Gulfstream Park, another Stronach-owned track.Midnight Storm returned $3 and $2.80 after winning six of his previous seven starts. Follow Me Crev was another 4 1/2 lengths back in third and paid $5 to show.“It was the first time running the mile and a quarter on dirt,” said Rafael Bejarano, who rode Midnight Storm. “He did a really good job.”After shipping in from Florida, Shaman Ghost stalked the pace in third before drifting out to the middle of the track in the stretch run before gaining the lead under Castellano’s urging in front of 29,412 on an unusually hot day.“I knew I had it won at the eighth pole,” Castellano said. “I asked him for full speed at the eighth pole and he gave it to me right away. I said, `Yes!’”Like Stronach, winning trainer Jimmy Jerkens also found some luck at Santa Anita. A year ago, he brought Effinex to the track for the Big `Cap only to have the horse finish third as the favorite after coming down with hives.Castellano moved Shaman Ghost to the outside, away from dirt flying in his face, as they turned for home.“He’s been showing up in all of his races,” Jerkens said, “so I think he should get some respect now.”The victory, worth $450,000, increased Shaman Ghost’s career earnings to $3,539,311, with seven wins in 15 starts.“With not a lot of speed in the race, I had to ask him a little, put him really close to the pace and he responded,” Castellano said. “Very classy horse.”The race was missing two big names among older horses: Arrogate and Hoppertunity. Both are set to run in Dubai later this month.Argentina-bred Hi Happy was fourth, followed by Isotherm, Hard Aces, Twentytwentyvision, Gangster and Imperative.In other stakes:_ Bal a Bali won the $400,345 Frank E. Kilroe Mile by a head over defending champion What a View.Ridden by Castellano, Brazil-bred Bal a Bali ran the distance in 1:33.86 and paid $22.20. He finished third last year.Dortmund was last in the six-horse field in his turf debut for trainer Art Sherman, extending his losing skid to five races dating to last year. Dortmund was previously trained by Bob Baffert before he and owner Kaleem Shah split._ Denman’s Call won the $400,690 Triple Bend Stakes by a length in an upset over 1-2 favorite Masochistic.Ridden by Tyler Baze, Denman’s Call ran seven furlongs in 1:20.94 and paid $35.40 to win.Masochistic won the race two years ago. He was making his first start since finishing second in the Breeders’ Cup Sprint last November and later being disqualified from the $255,000 purse money for testing positive for a steroid. By BETH HARRISAP Racing Writerlast_img

Ruff justice for Finn Harps mascot Harper following his dismissal against Sligo Rovers

first_imgWHEN HE TRIED – and failed in spectacular fashion it must be said – with an overhead kick in the pre-match warm-up, Finn Harps mascot Harper probably knew it wasn’t going to be his night, writes Alan Foley.Harper was on the field ahead of Harps’ Premier Division fixture against Sligo Rovers at Finn Park last night and tried to meet a deft cross with an audacious  effort – only to land flat on his face. Laugher rolled in from the terraces as Harper, showing pride over pain, jumped to his feet to give a wave of acknowledgment despite not getting a chance to show his Pedigree, Chum. Then, 27 minutes into the match with the score still 0-0, match referee Tommy Connolly stopped play and told a steward at the Town End of Finn Park to remove poor Harper, who was motioning to make saves behind the Rovers goal, which was being marshalled by Ed McGinty, a Motherwell native whose family come from Ballyshannon. Ruff justice indeed, although the steward did not lay a paw on him.After declaring his innocence and shrugging his shoulders a few times, poor Harper was removed from the end-line, much to the disappointment of both sets of supporters, who barked his innocence.Nathan Boyle, a minute later, scored the first of his two goals in Harps’ 2-0 win, although Twitter did show some sympathy for poor Harper, who may or may not be suspended for Monday’s visit of Cork City.Who ever said it’s a dog’s life? @alimason Noticed your comment on a post last night. Here’s the Finn Harps mascot being sent off during the game against Sligo Rovers.(Photo: Clare McCahill / Extratime) pic.twitter.com/eacN14aO31— Clare McCahill Photographer (@ClareMcCahill) June 29, 201927 min. The Finn Harps mascot has been sent off for pretending to save shots behind our goal (0-0) pic.twitter.com/71DhCTXGrM— Sligo Rovers (@sligorovers) June 28, 2019Does the Finn Harps mascot get a suspension?— Stephen Doyle (@dubsoulrebel) June 28, 2019my first day at work as the finn harps mascot has gone wonderfully— Patrick (@PrayForPatrick) June 28, 2019Ruff justice for Finn Harps mascot Harper following his dismissal against Sligo Rovers was last modified: June 29th, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:2019 League of Ireland First Divisionfinn harpsSligo Roverslast_img read more

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CM urges youth to be disciplined & work hard

first_imgGuwahati, Jul 28 (PTI) Assam Chief Minister Sarbananda Sonowal today urged youths to be disciplined, dedicated and work hard so that they can reach the zenith of success in sports.”Sports competitions help in honing talents of the budding sportsman and also help in inculcating zeal and dedication necessary for being a good player”, the Chief Minister said while inaugurating the ninth Mini (U-11) National Roll Ball Championship here today.He also pointed out that parents and teachers have a great role in helping students in inculcating and nurturing love for sports and take it up as a career.Prime Minister Narendra Modi has taken several steps for creating a favourable environment for development and spread of sports, he said.The programme called Khelo India was an effort to develop infrastructure and encourage talents in the country and to project India as a powerful nation in the global arena, he said.Steps have been taken to develop sports complex in all villages in the country and this has been made to explore and encourage sports talents in the rural areas, Sonowal said.Roll Ball has had its origin in India and then it went on to become popular across the globe, he added. PTI DG RG LNSlast_img read more

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10 months agoMourinho couldn’t get reaction from Man Utd players – Lascelles

first_imgMourinho couldn’t get reaction from Man Utd players – Lascellesby Freddie Taylor10 months agoSend to a friendShare the loveManchester United players lost faith in former manager Jose Mourinho, according to Newcastle United captain Jamaal Lascelles.United have won three straight games since Mourinho’s sacking.Ahead of Wednesday night’s clash with United, Lascelles said: “They probably needed that (a change at the top). They have world-class players on big wages who have done it for their countries and for other teams, but have not done it for Manchester United.”Some players can only play for certain managers and that reaction you get from the players.”Maybe (Solskjaer) might be the difference in getting the best from those players. They have a lot of quality. It will be an exciting game.” About the authorFreddie TaylorShare the loveHave your saylast_img read more

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Pacific Basin to Pay USD 74 Mn for Bulker Quartet

first_imgzoomIllustration; Image Courtesy: Pacific Basin Hong Kong-based dry bulk shipping company Pacific Basin has entered into a conditional agreement to acquire four secondhand dry bulk vessels for USD 73.84 million, that would be 33% funded by equity.The units include two 35,900 dwt Handysizes, built in 2015, that are scheduled for delivery in October-November 2019 and March-April 2020.The deal is also for two Supramaxes, featuring 61,400 dwt and 57,600 dwt, and built in 2012 and 2015, respectively. These two bulkers are also set to join their new owner in October-November 2019 and March-April 2020.The three 2015-built ships are currently under long-term time charter to Pacific Basin, with one charter deal expiring in October 2019 and two expiring in 2022. The purchase of these vessels will replace the company’s charter costs “with significantly lower owned vessel cash costs”.The consideration will take the form of 105,9 million new Pacific Basin shares to be issued to the ships’ sellers amounting to USD 24.37 million in aggregate, and USD 49.47 million to be funded from the group’s cash.The new shares to be issued will in aggregate represent 2.22% of Pacific Basin’s enlarged issued share capital after the allotment and issue of all these new shares. The issue price of HKD 1.80 per new share issued to the ships’ sellers represents a premium of 5.94% to the average closing price for the last ten trading days.“Consistent with our previously stated goal of looking opportunistically but cautiously at acquiring good quality secondhand ships, these ship purchases represent another attractive opportunity to grow and renew our fleet with modern, efficient vessels built by large, reputable shipbuilders Shikoku, Tsuneishi and Imabari,” Mats Berglund, CEO of Pacific Basin, said.last_img read more

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William Shatner And Wells Fargo Will Host Breakfast Gifting Ceremony

first_imgWilliam Shatner, one of America’s most versatile stars and philanthropists, formally announced today that he and David DiCristofaro, Wells Fargo Greater Los Angeles Bank President, will host a gifting ceremony and media breakfast to distribute grants to the charities supported by the annual Priceline.com Hollywood Charity Horse Show, Sponsored by Wells Fargo.The Hollywood Charity Horse Show is in its 25th year.The event will begin at 8:00 AM on Thursday, February 5th at The Six Restaurant, 12650 Ventura Blvd., Studio City, CA.Proceeds from the Priceline.com Hollywood Charity Horse Show, Sponsored by Wells Fargo benefit special-needs children across the City of Los Angeles through local charities including: AHEAD With Horses, Children’s Hospital Los Angeles, Hollenbeck Police Activities League (PAL), The Painted Turtle and others.“Over the last 25 years, we have been able to help thousands of young Angelinos thanks to the support we receive from our generous sponsors and attendees,” commented William Shatner. “We are so happy to award the funds raised at the 2014 event to these special-needs organizations.”last_img read more

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